Theresa Lüth

PhD Student

Name: Theresa Lüth Position/Title: PhD Student Address: University of Lübeck and University Hospital Schleswig-Holstein BMF, Building 67, Room 57.00 Ratzeburger Allee 160 23538 Lübeck Germany Phone: +49-451-31018239 Fax: +49-451-31018204 Email: t.lueth@uni-luebeck.de

March 2021, March 2022, May 2023: Teaching Assistant in Third-generation sequencing consolidation course at the University of Lübeck, Institute of Neurogenetics.

2020 February – 2020 March: Internship at the University of Lübeck,
Department of Infectious Diseases and Microbiology (Supervisor: Dr.
Simon Graspeuntner).

2019 October – 2020 January: Internship at the University of Lübeck, Institute of Neurogenetics (Supervisor: PD Dr. Joanne Trinh).

2017 October: Student Assistant – Support of the cell practical biology training at the University of Lübeck, Institute of virology and cell biology

2015 October – 2016 July: Student Assistant – Support of the practical chemistry training at the University of Lübeck, Institute of Chemistry

  • Kathleen Schlüter (former MSc student)
    Description: Co-supervision for thesis project
  • Joshua Lass (former MSc student)
    Description: Co-supervision for MLS internship practical studies and thesis project
  • Gabbert C, Blöbaum L, Lüth T, König IR, Caliebe A, Koch S, Björn-Hergen L, Klein C, Trinh J. The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease. medRxiv 2023;in press.
  • Lüth T, Gabbert C, Koch S, König IR, Caliebe A, Laabs BH, Hentati F, Sassi SB, Amouri R, Spielmann M, Klein C, Grünewald A, Farrer MJ, Trinh J. Interaction of Mitochondrial Polygenic Score and Lifestyle Factors in LRRK2 p.Gly2019Ser Parkinsonism. Mov Disord 2023;10:1837-1849.
  • Gabbert C, Schaake S, Lüth T, Much C, Klein C, Aasly JO, Farrer MJ, Trinh J. GBA1 in Parkinson's disease: variant detection and pathogenicity scoring matters. BMC Genomics 2023;1:322.
  • Gabbert C, König IR, Lüth T, Kasten M, Grünewald A, Klein C, Trinh J. Lifestyle factors and clinical severity of Parkinson's disease. Sci Rep 2023;1:9537.
  • Saffie Awad P, Lohmann K, Hirmas Y, Hinrichs F, Thomsen M, Kauffman M, Lüth T, Trinh J, Westenberger A, Chaná-Cuevas P, Klein C. Shaking Up Ataxia: FGF14 and RFC1 Repeat Expansions in Affected and Unaffected Members of a Chilean Family. Mov Disord 2023;6:1107-1109.
  • Borsche M, Dulovic-Mahlow M, Baumann H, Tunc S, Lüth T, Schaake S, Özcakir S, Westenberger A, Münchau A, Knappe E, Trinh J, Brüggemann N, Lohmann K. POLG2-Linked Mitochondrial Disease: Functional Insights from New Mutation Carriers and Review of the Literature. Cerebellum 2023;2:479-488.
  • Trinh J, Hicks AA, König IR, Delcambre S, Lüth T, Schaake S, Wasner K, Ghelfi J, Borsche M, Vilariño-Güell C, Hentati F, Germer EL, Bauer P, Takanashi M, Kostić V, Lang AE, Brüggemann N, Pramstaller PP, Pichler I, Rajput A, Hattori N, Farrer MJ, Lohmann K, Weissensteiner H, May P, Klein C, Grünewald A. Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson's disease. Brain 2022;in press.
  • Lüth T, Graspeuntner S, Neumann K, Kirchhoff L, Masuch A, Schaake S, Lupatsii M, Tse R, Griesinger G, Trinh J, Rupp J. Improving analysis of the vaginal microbiota of women undergoing assisted reproduction using nanopore sequencing. J Assist Reprod Genet 2022;11:2659-2667.
  • Lüth T, Schaake S, Grünewald A, May P, Trinh J, Weissensteiner H. Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA. Front Genet 2022:887644.
  • Trinh J, Lüth T, Schaake S, Laabs BH, Schlüter K, Laβ J, Pozojevic J, Tse R, König I, Jamora RD, Rosales RL, Brüggemann N, Saranza G, Diesta CCE, Kaiser FJ, Depienne C, Pearson CE, Westenberger A, Klein C. Mosaic divergent repeat interruptions in XDP influence repeat stability and disease onset. Brain 2022;3:1075-1082.
  • Gabbert C, König IR, Lüth T, Kolms B, Kasten M, Vollstedt EJ, Balck A, Grünewald A, Klein C, Trinh J. Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease. J Neurol 2022;8:4195-4203.
  • Lüth T, Laβ J, Schaake S, Wohlers I, Pozojevic J, Jamora RDG, Rosales RL, Brüggemann N, Saranza G, Diesta CCE, Schlüter K, Tse R, Reyes CJ, Brand M, Busch H, Klein C, Westenberger A, Trinh J. Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in TAF1 with Nanopore Sequencing. Genes (Basel) 2022;1
  • Lüth T, Wasner K, Klein C, Schaake S, Tse R, Pereira SL, Laß J, Sinkkonen L, Grünewald A, Trinh J. Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept. Front Aging Neurosci 2021:713084.
  • Reyes CJ, Laabs BH, Schaake S, Lüth T, Ardicoglu R, Rakovic A, Grütz K, Alvarez-Fischer D, Jamora RD, Rosales RL, Weyers I, König IR, Brüggemann N, Klein C, Dobricic V, Westenberger A, Trinh J. Brain Regional Differences in Hexanucleotide Repeat Length in X-Linked Dystonia-Parkinsonism Using Nanopore Sequencing. Neurol Genet 2021;4:e608.
  • Lüth T, König IR, Grünewald A, Kasten M, Klein C, Hentati F, Farrer M, Trinh J. Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors. Mov Disord 2020;10:1854-1858.

    • 1. Charles Reyes, Theresa Lüth, Joanne Trinh. Analysis of a Hexanucleotide Repeat Domain in the
    TAF1 SVA Retrotransposon in X-linked dystonia-parkinsonism. Springer Protocols Book Chapter.
    2021 (Genomic Structural Variants in Nervous System Disorders. 2022 DOI:
    doi.org/10.1007/978-1-0716-2357-2_8)
    (*=equal contribution)

    1. Theresa Lüth, Inke König, Anne Grünewald, Meike Kasten, Christine Klein, Faycel Hentati,
      Matthew Farrer, Joanne Trinh. Age at onset of LRRK2 p.Gly2019Ser is related to environmental
      and lifestyle factors. Congress of the German Society of Neurology. November 04-11, 2020.
    2. Theresa Lüth, Aurelien Ginolhac, Christine Klein, Susen Schaake, Ronnie Tse, Sandro Pereira,
      Lasse Sinkkonen, Anne Grünewald, Joanne Trinh. Nanopore sequencing detects low-level
      methylation of the mitochondrial genome. Genomics for Health — Annual Meeting of the AGD.
      December 17-18, 2020.
    3. Theresa Lüth, Inke König, Anne Grünewald, Meike Kasten, Christine Klein, Faycel Hentati,
      Matthew Farrer, Joanne Trinh. Age at onset of LRRK2 p.Gly2019Ser is related to environmental
      and lifestyle factors. German Congress of Parkinson and Movement Disorders. March 04-06,
      2021.
    4. Theresa Lüth, Kobi Wasner, Christine Klein, Susen Schaake, Ronnie Tse, Sandro Pereira, Joshua
      Lass, Lasse Sinkkonen, Anne Grünewald, Joanne Trinh. Nanopore single-molecule sequencing
      to investigate mitochondrial DNA CpG methylation in Parkinson’s disease. International
      Movement Disorder Society Virtual Congress September 17-22, 2021.
    5. Theresa Lüth, Carolin Gabbert, Panna Lajer, Inke R. König, Amke Caliebe, Sebastian Koch,
      Björn-Hergen Laabs, Faycel Hentati, Samia Ben Sassi, Rim Amouri, Christine Klein, Anne
      Grünewald, Matthew J. Farrer, Joanne Trinh. The mitochondrial risk score, lifestyle factors and
      environmental exposure are associated with age at onset in LRRK2 p.Gly2019Ser and
      idiopathic Parkinson’s disease. Movement Disorder Society Congress September 15-18 2022.
    1. Theresa Lüth, Kobi Wasner, Christine Klein, Susen Schaake, Ronnie Tse, Sandro Pereira, Joshua
      Lass, Lasse Sinkkonen, Anne Grünewald, Joanne Trinh. Nanopore single-molecule sequencing
      to investigate mitochondrial DNA CpG methylation in Parkinson’s disease. London Calling
      2021. May 19-21, 2021.
    2. Joanne Trinh, Theresa Lüth, Susen Schaake, Björn-Hergen Laabs, Kathleen Schlüter, Joshua
      Laβ, Jelena Pozojevic, Ronnie Tse, Inke König, Roland Dominic Jamora, Raymond L Rosales,
      Norbert Brüggemann, Gerard Saranza, Cid Czarina E Diesta, Frank J Kaiser, Christel Depienne,
      Christopher E Pearson, Ana Westenberger, Christine Klein. Mosaic divergent repeat
      interruptions in XDP influence repeat stability and di
    1. Genomics for Health — Annual Meeting of the AGD poster prize (200€)